Blogging the biotechnology revolution

Systems Biology is changing the way biology is done. Is it a fad or is it effective? This blog tracks current happenings and helps you stay on top of the field. You can find a list of relevant papers at systems biology paper watch Have you heard a talk or read a paper in bioinformatics / systems biology you would like to tell other people about? Email: and get the word out!

Friday, December 02, 2005

Douglas Lauffenburger, MIT
"Multivariate Cue/Signal/Response Analysis of Cell Decision Processes"

Talked about interesting methods for the survey of signal transduction. Looks at temporal (dynamic) activation over short time points using protein abundance as wall as kinase activity all on a chip. They find that different phosphorylation sites are activated at different times. This is done using a novel mass spec labeling method. This means that its site-specific response that matters not the abundance as traditionally assumed. He mentions that the data set is very rich and ripe for data mining using bayesian approaches.


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