I just ran across an interesting paper in Nature on the genetic basis of tumor susceptibility and skin inflammation. The authors use backcrossed mice to identify eQTLs and mapped these onto a network for co-expression based on various skin expression profiles. The expression profiles highlighted skin specific networks such as keratins. Their analysis suggests to me that using a generic co-expression network would not have given them the results that a "local" co-expression network which is based on skin expression which is the system they are interested in. Overall the paper presents an interesting approach for applying networks to eQTL analysis
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The biotechnology or genomics revolution refers to the massive impacts of new technologies that allow life to be manipulated at its most basic level, genes.
SADAS
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