Richard Karp, Berkeley
"An integrated approach to the reconstruction of molecular networks"
Mentioned the flow cytometry approach of lauffenbeger an emerging way to measure abundances accutaely in single cells. Currently can only do up to 13 proteins at once. Using this data they are trying to reconstruct the networks.
sAt the end of the talk showed evidence that the netowrk topology (arrows) are more important than simply the paramters using cilia and flagellar(?) data from previous papers. In particular with wrong topology never get to predict the correct phenotype but with the correct topology and random parameters get the proper prediciton 0.005% of the time.