Blogging the biotechnology revolution

Systems Biology is changing the way biology is done. Is it a fad or is it effective? This blog tracks current happenings and helps you stay on top of the field. You can find a list of relevant papers at systems biology paper watch Have you heard a talk or read a paper in bioinformatics / systems biology you would like to tell other people about? Email: and get the word out!

Friday, December 02, 2005

Aviv Regev, Harvard University
"Trees and Forests: How do molecular networks accommodate change?"
Studied the evolution of functional modules from gene expression data in various yeasts. Using a definition of modules as reciprocal best blast hits. Using co-expression from cerevisiae and pombe infer these modules in ~20 other yeast related species.
Also tries to reconstruct evolutionary history of modules by looking at the character of the whole promoter region (duplications, deletions, inversions etc).
Also work toward a general framework for module phylogeny. Module membership changes over time. Also module topology (network) changes over time. Module flux changes as members change as well.

Ilan Wapinsnki is developing method for resolution of orthologs using phyogenetic history. Look for this in the future.


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