Blogging the biotechnology revolution

Systems Biology is changing the way biology is done. Is it a fad or is it effective? This blog tracks current happenings and helps you stay on top of the field. You can find a list of relevant papers at systems biology paper watch Have you heard a talk or read a paper in bioinformatics / systems biology you would like to tell other people about? Email: and get the word out!

Sunday, December 04, 2005

Michael G. Rosenfeld, UCSD
"Coactivator and Corepressor Networks Integrated Transcriptional Response Programs"

Transcriptional regulation is done by exchange of activators and co-repressors on the binding sites.
Uses a variation of chip-chip called chip-dsl-chip where they biotinynlate the RNA and use 40 mer primers to ligate small fragments that can be detected on a chip (this avoids the random sizes of sonication problem in traditional chip-chip)

Most profound in this talk is the notion that there is some interplay between the transcriptional activation machinery and PARP1 which is known to be involved in NDA-damage response. This led to the idea that there is a DNA double strand nick that is associated with transcriptional activation caused by TopoIIb.


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